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KMID : 0359420030210010070
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Korean Journal of Sports Medicine
2003 Volume.21 No. 1 p.70 ~ p.77
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Effects of Endurance Exercise on Tumor Formation in Renca Mouse Tumor Model
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Jo Jung-Jea
Kim Chang-Ju
Kim Sung-Soo
An Hyun-Jong
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Abstract
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Subcutaneous injection of cells from renal adenocarcinoma line. renca. into Balb/c mice induces fast growing solid tumors. This method has been used to speculate the efficacy of cytokine treatment for tumor regression. The present study was designed to investigate the effect of treadmill exercise on tumor growth using renca mouse tumor model. We also examined the expression pattern of several genes related to immune response after exercise training for 4 weeks. Exercise training reduced the size of tumor mass compared to that of non-exercised group in tumor cell recipient mice. Natural killer (NK) cell activity showed no significant difference between exercised and non-exercised groups in tumor cell non-recipient mice. Although NK cell activity of non-recipients was higher than tumor cell recipients, NK cell activity of exercised group was significantly lower than non-exercised group among tumor cell recipients. There were no significant differences in mRNA expressions of cytokines, scavenger receptors, and neuropeptides which are related to immune response, while mRNA expression of TGF-beta was significantly reduced both in spleen and in tumor mass by treadmill exercise. Based on the results presented in this study, endurance exercise has shown the possibility to suppress tumor formation.
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KEYWORD
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Endurance exercise, Tumor formation, NK cell, TGF-beta
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